As in 2021, the overdose death rate was highest among American Indian and Alaska Native people, jumping 15% in 2022, according to the latest CDC data. Overdose death rates also increased among Black, Hispanic and Asian people but decreased among White people.

While deaths from heroin and natural opioids such as morphine and oxycodone decreased, deaths from fentanyl and other synthetic opioids continued their steep upward trend. There were about 23 deaths from synthetic opioids other than methadone for every 100,000 people in 2022, more than double the rate from five years earlier and 4% higher than in 2021.

The rate of overdose deaths involving cocaine spiked in 2022, rising more than 12% in just one year. Deaths involving psychostimulants also increased in 2022, rising 4% year-over-year.